E-Selectin/CD62E His Tag Protein, Cynomolgus
SKU: 73272109353

E-Selectin/CD62E His Tag Protein, Cynomolgus

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Description

E-Selectin/CD62E His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM 1, SELE, Selectin E, CD62 Antigen Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2 Accession XP_005539998. 2 Concentration 95% by SDS PAGE & SEC HPLC Amino Acid Sequence Trp22 Pro556 with His Tag at the C Terminus

Product Specification


Species Cynomolgus
Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM-1, SELE, Selectin E, CD62 Antigen-Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte-Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2
Accession XP_005539998.2
Concentration >95% by SDS-PAGE & SEC-HPLC
Amino Acid Sequence

Trp22-Pro556 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight

90-110kDa (Reducing)

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Liu ZJ, Tian R, An W, Zhuge Y, Li Y, Shao H, et al.. Identification ofE-selectin as a novel target for the regulation of post-natalneovascularization: implications for diabetic wound healing. Ann Surg. (2010)252:625–34.

Background

E-Selectin, officially known as Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1) or CD62E, is a member of the Selectin family of cell surface glycoproteins with a molecular weight ranging from 107 to 115 kDa. This cell adhesion molecule plays a pivotal role in inflammation and neovascularization, particularly in wound healing and ischemic areas.
Upon tissue injury, the release of cytokines and chemokines, such as stromal cell-derived factor 1α (SDF-1α), triggers the local expression of membrane-bound E-Selectin on endothelial cells. Concurrently, it induces the expression of systemic reciprocal E-Selectin ligands on endothelial progenitor cells (EPCs) within the bone marrow, mediated by the C-X-C motif chemokine receptor 4 (CXCR4).
E-Selectin is transiently expressed on vascular endothelial cells in response to cytokines like IL-1 beta and TNF-alpha, peaking at 4 hours post-activation and decaying by 24 hours. This cell surface glycoprotein is integral to immune cell adhesion, specifically by interacting with SELPLG/PSGL1 on blood neutrophils, which facilitates their adhesion to cytokine-activated endothelium. E-Selectin may also contribute to capillary morphogenesis.
During inflammation, E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall by binding to E-Selectin ligands present on leukocytes. These initial interactions are dynamic, allowing leukocytes to roll along the vascular endothelium in the direction of blood flow. Subsequently, stronger interactions involving ICAM-1 and VCAM-1 lead to the extravasation of white blood cells through the blood vessel wall and into the extracellular matrix of surrounding tissues.

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SKU: 73272109353

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Scgirlie
West Palm Beach, US
★★★★★ 5
Surprisingly good!
Format: Kindle
I wasn’t sure I could forgive them and that’s always my issue with betrayal books - can I forgive the mmc, plural in this case, but the author was absolutely able to get me to that point. Yea I struggled with one them especially but overall I loved the book!! Followed the author immediately
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Reviewed in the United States on December 29, 2025
M
mandie
Lowell, US
★★★★★ 4
Amazing read!!
Format: Kindle
Where to begin. I loved this book. The characters had a way of pulling you in and making you holding your breath at the same time. I absolutely loved the fmc. Eva has a way of being vulnerable but strong. She is unwilling to give up. The mmc’s are truly horrible at the beginning. With that being said, I still found myself rooting for them. Over time you could them changing and how even when they wanted to hate her they just couldn’t find it in them. A truly remarkable love came from a terrible beginning. Loved it!
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Reviewed in the United States on December 12, 2025
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S.O.
New York, US
★★★★★ 3
Not bad but read better omegaverse
Format: Kindle
Mmm. I have feelings. Some not good. Some good. It was an ok read. I've been on a omegaverse kick for awhile now. Love me some groveling alphas but this wasn't it. Actually there wasn't enough groveling and the fmc gave in WAY too quickly. They all have f'ed childhood. The alphas, Dorian, Rafe and Cade met at an orphanage that did unspeakable things to them until Dorian and Rafe aged out at 18 and had ti wait a few years until they could "adopt" Cade, who was 3 years younger than them. They all become successful entrepreneur of sort, I think. They created an app called HeatLink. The fmc, Eva, was sold to the pack by her horrible, abusing father. She endured just as much hardship. She is relentless with escaping the pack but she always gave in when they got too near. Like she couldn't keep her legs closed. She hates them but gave in everytime. I found her kind of weak in that sense. The overall plot was fine. Didn't leave me yearning to read the next page. I did clock one of the identity of someone quickly though. Don't want to spoil it. Again, I've read better omegaverse books. The one good thing about the book is one of the lines from Cade on page 218: ""Please Eva. I'm sorry." She staggered back and I followed her on my knees, dragging myself. I didn't care. I just wanted her to hold me."" I'll admit, I melted a little bit for Cade, even though he was probably the worse a-hole out of the bunch.
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Reviewed in the United States on January 9, 2026
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LaChante Anderson
Pawtucket, US
★★★★★ 5
Good Groveling!
Format: Kindle
⭐️⭐️⭐️⭐️.5|🌶️🌶️🌶️🌶️.5 This was really good! Definitely a dark romance! The plot was really good and was done well. I enjoyed the character development but I did wish the FMC told her pack she loved them at the end. Overall I would recommend this to readers who like bully romances and groveling! 💖
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Reviewed in the United States on February 24, 2026
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Alice Wonder
Massapequa, US
★★★★★ 2
it went on too long…
Format: Kindle
At first it was a good read and I was really into it then it got to be a little to much with every page being more about how “slick” she was or about constant sex… I like spice don’t get me wrong but this was just a little too much after a while and the plot was lost. I also felt like the ending was weird and awkward it was just a good build up to fall flat
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Reviewed in the United States on May 23, 2026

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